Crystal structure of the DesK-DesR complex in the phosphatase state

Summary for 5IUN

Related5IUJ 5IUK 5IUL 5IUM
DescriptorSensor histidine kinase DesK, Transcriptional regulatory protein DesR, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (8 entities in total)
Functional Keywordstwo-component regulatory system, kinase, response regulator, phosphatase complex, dephosphorylation, transferase, transferase-gene regulation complex, transferase/gene regulation
Biological sourceBacillus subtilis
Cellular locationCell membrane ; Multi-pass membrane protein  O34757
Cytoplasm  O34723
Total number of polymer chains6
Total molecular weight124078.99
Trajtenberg, F.,Imelio, J.A.,Larrieux, N.,Buschiazzo, A. (deposition date: 2016-03-18, release date: 2016-12-21, Last modification date: 2017-11-22)
Primary citation
Trajtenberg, F.,Imelio, J.A.,Machado, M.R.,Larrieux, N.,Marti, M.A.,Obal, G.,Mechaly, A.E.,Buschiazzo, A.
Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action.
Elife, 5:-, 2016
PubMed: 27938660 (PDB entries with the same primary citation)
DOI: 10.7554/eLife.21422
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26750.1%4.7%14.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5iun
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Molmil generated image of 5iun
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Molmil generated image of 5iun
rotated about y axis by 90°
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