Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5IUH

Crystal Structure of the Anaplastic Lymphoma Kinase (ALK) in complex with 5d

Summary for 5IUH
Entry DOI10.2210/pdb5iuh/pdb
Related5IUG 5IUI
DescriptorALK tyrosine kinase receptor, 4-[(4-methylpiperazin-1-yl)methyl]-N-{3-[3-methyl-4-({[5-(propan-2-yl)-1,2-oxazol-3-yl]carbamoyl}amino)phenyl]-1H-pyrazol-5-yl}benzamide (3 entities in total)
Functional Keywordscatalytic domain, transferase
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane ; Single-pass type I membrane protein : Q9UM73
Total number of polymer chains1
Total formula weight37389.86
Authors
Tu, C.H.,Wu, S.Y. (deposition date: 2016-03-18, release date: 2016-05-18, Last modification date: 2024-03-20)
Primary citationTu, C.H.,Lin, W.H.,Peng, Y.H.,Hsu, T.,Wu, J.S.,Chang, C.Y.,Lu, C.T.,Lyu, P.C.,Shih, C.,Jiaang, W.T.,Wu, S.Y.
Pyrazolylamine Derivatives Reveal the Conformational Switching between Type I and Type II Binding Modes of Anaplastic Lymphoma Kinase (ALK).
J.Med.Chem., 59:3906-3919, 2016
Cited by
PubMed: 27031565
DOI: 10.1021/acs.jmedchem.6b00106
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

数据于2024-03-27公开中

PDB statisticsPDBj update infoContact PDBjnumon