5IUH

Crystal Structure of the Anaplastic Lymphoma Kinase (ALK) in complex with 5d

5IUH の概要

• エントリーDOI: 10.2210/pdb5iuh/pdb
• 関連するPDBエントリー: 5IUG 5IUI
• 分子名称: ALK tyrosine kinase receptor, 4-[(4-methylpiperazin-1-yl)methyl]-N-{3-[3-methyl-4-({[5-(propan-2-yl)-1,2-oxazol-3-yl]carbamoyl}amino)phenyl]-1H-pyrazol-5-yl}benzamide (3 entities in total)
• 機能のキーワード: catalytic domain, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein : Q9UM73
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37389.86

構造登録者

Tu, C.H.,Wu, S.Y. (登録日: 2016-03-18, 公開日: 2016-05-18, 最終更新日: 2024-03-20)

• 主引用文献: Tu, C.H.,Lin, W.H.,Peng, Y.H.,Hsu, T.,Wu, J.S.,Chang, C.Y.,Lu, C.T.,Lyu, P.C.,Shih, C.,Jiaang, W.T.,Wu, S.Y.; Pyrazolylamine Derivatives Reveal the Conformational Switching between Type I and Type II Binding Modes of Anaplastic Lymphoma Kinase (ALK).; J.Med.Chem., 59:3906-3919, 2016; PubMed: 27031565; DOI: 10.1021/acs.jmedchem.6b00106

実験手法

X-RAY DIFFRACTION (2.1 Å)