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5IUB

Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with compound 12x at 2.1A resolution

Summary for 5IUB
Entry DOI10.2210/pdb5iub/pdb
Related5IU4 5IU7 5IU8 5IUA
DescriptorAdenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, SODIUM ION, N~5~-{2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethyl}-2-(furan-2-yl)[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine, ... (8 entities in total)
Functional Keywordsg-protein-coupled receptor, integral membrane protein, chimera, thermostabilizing mutations, membrane protein
Biological sourceHomo sapiens (Human)
More
Cellular locationCell membrane; Multi-pass membrane protein: P29274
Total number of polymer chains1
Total formula weight57349.37
Authors
Segala, E.,Guo, D.,Cheng, R.K.Y.,Bortolato, A.,Deflorian, F.,Dore, A.S.,Errey, J.C.,Heitman, L.H.,Ijzerman, A.P.,Marshall, F.H.,Cooke, R.M. (deposition date: 2016-03-17, release date: 2016-06-29, Last modification date: 2024-01-10)
Primary citationSegala, E.,Guo, D.,Cheng, R.K.,Bortolato, A.,Deflorian, F.,Dore, A.S.,Errey, J.C.,Heitman, L.H.,IJzerman, A.P.,Marshall, F.H.,Cooke, R.M.
Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength.
J.Med.Chem., 59:6470-6479, 2016
Cited by
PubMed: 27312113
DOI: 10.1021/acs.jmedchem.6b00653
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

數據於2024-03-27公開中

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