5IU8
Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with compound 12f at 2.0A resolution
Summary for 5IU8
Entry DOI | 10.2210/pdb5iu8/pdb |
Related | 5IU4 5IU7 |
Descriptor | Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, SODIUM ION, 2-(furan-2-yl)-N~5~-[2-(4-methylpiperazin-1-yl)ethyl][1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine, ... (9 entities in total) |
Functional Keywords | g-protein-coupled receptor, integral membrane protein, chimera, thermostabilizing mutationsm, membrane protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P29274 |
Total number of polymer chains | 1 |
Total formula weight | 57563.94 |
Authors | Segala, E.,Guo, D.,Cheng, R.K.Y.,Bortolato, A.,Deflorian, F.,Dore, A.S.,Errey, J.C.,Heitman, L.H.,Ijzerman, A.P.,Marshall, F.H.,Cooke, R.M. (deposition date: 2016-03-17, release date: 2016-06-29, Last modification date: 2024-01-10) |
Primary citation | Segala, E.,Guo, D.,Cheng, R.K.,Bortolato, A.,Deflorian, F.,Dore, A.S.,Errey, J.C.,Heitman, L.H.,IJzerman, A.P.,Marshall, F.H.,Cooke, R.M. Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength. J.Med.Chem., 59:6470-6479, 2016 Cited by PubMed: 27312113DOI: 10.1021/acs.jmedchem.6b00653 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.002 Å) |
Structure validation
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