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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5IUB

Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with compound 12x at 2.1A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001609	molecular_function	G protein-coupled adenosine receptor activity
A	0001973	biological_process	G protein-coupled adenosine receptor signaling pathway
A	0004930	molecular_function	G protein-coupled receptor activity
A	0005506	molecular_function	iron ion binding
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue NA A 2400

Chain	Residue
A	ASP52
A	SER91
A	HOH2524
A	HOH2552
A	HOH2564

site_id	AC2
Number of Residues	18
Details	binding site for residue 6DV A 2401

Chain	Residue
A	TRP246
A	LEU249
A	HIS250
A	ASN253
A	HIS264
A	ALA265
A	PRO266
A	LEU267
A	MET270
A	ILE274
A	HOH2560
A	HOH2566
A	HOH2569
A	HOH2573
A	LEU85
A	PHE168
A	GLU169
A	MET177

site_id	AC3
Number of Residues	7
Details	binding site for residue CLR A 2402

Chain	Residue
A	ALA72
A	ALA73
A	GLY76
A	ILE80
A	CLR2404
A	OLB2421
A	OLB2424

site_id	AC4
Number of Residues	3
Details	binding site for residue CLR A 2403

Chain	Residue
A	PRO248
A	SER263
A	OLB2422

site_id	AC5
Number of Residues	9
Details	binding site for residue CLR A 2404

Chain	Residue
A	LEU247
A	CYS254
A	PHE255
A	CYS259
A	CLR2402
A	OLA2419
A	OLB2421
A	OLB2424
A	HOH2563

site_id	AC6
Number of Residues	3
Details	binding site for residue OLA A 2405

Chain	Residue
A	THR65
A	OLB2422
A	OLB2424

site_id	AC7
Number of Residues	1
Details	binding site for residue OLA A 2406

Chain	Residue
A	PRO266

site_id	AC8
Number of Residues	4
Details	binding site for residue OLA A 2407

Chain	Residue
A	PHE44
A	ALA97
A	VAL116
A	HOH2508

site_id	AC9
Number of Residues	5
Details	binding site for residue OLA A 2408

Chain	Residue
A	GLY5
A	SER6
A	LEU267
A	TYR271
A	HOH2506

site_id	AD1
Number of Residues	7
Details	binding site for residue OLA A 2409

Chain	Residue
A	LEU96
A	ILE127
A	LEU131
A	ALA184
A	LEU192
A	OLA2412
A	OLC2429

site_id	AD2
Number of Residues	1
Details	binding site for residue OLA A 2410

Chain	Residue
A	OLB2422

site_id	AD3
Number of Residues	4
Details	binding site for residue OLA A 2411

Chain	Residue
A	SER7
A	LEU19
A	TRP29
A	PHE286

site_id	AD4
Number of Residues	4
Details	binding site for residue OLA A 2412

Chain	Residue
A	GLY123
A	VAL130
A	OLA2409
A	HOH2503

site_id	AD5
Number of Residues	5
Details	binding site for residue OLA A 2413

Chain	Residue
A	TRP32
A	LEU198
A	PHE201
A	LYS233
A	OLB2426

site_id	AD6
Number of Residues	4
Details	binding site for residue OLA A 2414

Chain	Residue
A	ILE3
A	SER7
A	VAL18
A	OLB2427

site_id	AD7
Number of Residues	1
Details	binding site for residue OLA A 2416

Chain	Residue
A	GLY76

site_id	AD8
Number of Residues	1
Details	binding site for residue OLA A 2417

Chain	Residue
A	LEU244

site_id	AD9
Number of Residues	4
Details	binding site for residue OLA A 2418

Chain	Residue
A	VAL12
A	THR279
A	VAL283
A	OLA2420

site_id	AE1
Number of Residues	3
Details	binding site for residue OLA A 2419

Chain	Residue
A	LEU194
A	ALA243
A	CLR2404

site_id	AE2
Number of Residues	2
Details	binding site for residue OLA A 2420

Chain	Residue
A	ILE287
A	OLA2418

site_id	AE3
Number of Residues	6
Details	binding site for residue OLB A 2421

Chain	Residue
A	LEU187
A	PHE258
A	CLR2402
A	CLR2404
A	OLC2428
A	HOH2563

site_id	AE4
Number of Residues	6
Details	binding site for residue OLB A 2422

Chain	Residue
A	CLR2403
A	OLA2405
A	OLA2410
A	OLB2424
A	PHE255
A	CYS262

site_id	AE5
Number of Residues	3
Details	binding site for residue OLB A 2423

Chain	Residue
A	LEU137
A	OLC2429
A	HOH2567

site_id	AE6
Number of Residues	8
Details	binding site for residue OLB A 2424

Chain	Residue
A	VAL57
A	THR65
A	PHE70
A	CYS71
A	CLR2402
A	CLR2404
A	OLA2405
A	OLB2422

site_id	AE7
Number of Residues	3
Details	binding site for residue OLB A 2425

Chain	Residue
A	TYR43
A	LEU58
A	GLY118

site_id	AE8
Number of Residues	5
Details	binding site for residue OLB A 2426

Chain	Residue
A	GLN38
A	TYR43
A	VAL46
A	ARG205
A	OLA2413

site_id	AE9
Number of Residues	3
Details	binding site for residue OLB A 2427

Chain	Residue
A	SER6
A	THR68
A	OLA2414

site_id	AF1
Number of Residues	5
Details	binding site for residue OLC A 2428

Chain	Residue
A	TYR179
A	PHE257
A	PHE258
A	OLB2421
A	OLC2429

site_id	AF2
Number of Residues	11
Details	binding site for residue OLC A 2429

Chain	Residue
A	HIS75
A	MET140
A	LEU141
A	GLY142
A	ASN144
A	TYR179
A	ALA184
A	OLA2409
A	OLB2423
A	OLC2428
A	HOH2567

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSIfSLLAIAIDRYIaI

Chain	Residue	Details
A	SER90-ILE106

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	VAL8-TRP32

site_id	SWS_FT_FI2
Number of Residues	28
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:18832607

Chain	Residue	Details
A	LEU33-ASN42
A	ASP101-ARG120

site_id	SWS_FT_FI3
Number of Residues	23
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	TYR43-ILE66

site_id	SWS_FT_FI4
Number of Residues	46
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:18832607

Chain	Residue	Details
A	SER67-CYS77
A	ASN144-PRO173
A	CYS259-PRO266

site_id	SWS_FT_FI5
Number of Residues	22
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	LEU78-ILE100

site_id	SWS_FT_FI6
Number of Residues	22
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	ALA121-TRP143

site_id	SWS_FT_FI7
Number of Residues	24
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	MET174-LEU198

site_id	SWS_FT_FI8
Number of Residues	23
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	ALA235-PHE258

site_id	SWS_FT_FI9
Number of Residues	23
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	LEU267-TYR290

site_id	SWS_FT_FI10
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:21593763, ECO:0007744\|PDB:2YDO

Chain	Residue	Details
A	GLU169
A	ASN253
A	ALA277
A	HIS278

site_id	SWS_FT_FI11
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ALA154

site_id	SWS_FT_FI12
Number of Residues	2
Details	BINDING: axial binding residue

Chain	Residue	Details
A	TRP1007
A	ILE1102

218853

PDB entries from 2024-04-24

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