5INF

Structural basis for acyl-CoA carboxylase-mediated assembly of unusual polyketide synthase extender units incorporated into the stambomycin antibiotics

Summary for 5INF

Entry DOI	10.2210/pdb5inf/pdb
Related	5ING 5INI
Descriptor	Carboxyl transferase, HEXANOYL-COENZYME A (3 entities in total)
Functional Keywords	polyketide, crotonase, extender-unit, acyl-coa, transferase
Biological source	Streptomyces ambofaciens ATCC 23877
Total number of polymer chains	6
Total formula weight	349469.52
Authors	Valentic, T.R.,Ray, L.,Miyazawa, T.,Withall, D.M.,Song, L.,Osada, H.,Tsai, S.C.,Challis, G.L. (deposition date: 2016-03-07, release date: 2016-12-28, Last modification date: 2023-09-27)
Primary citation	Ray, L.,Valentic, T.R.,Miyazawa, T.,Withall, D.M.,Song, L.,Milligan, J.C.,Osada, H.,Takahashi, S.,Tsai, S.C.,Challis, G.L. A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units. Nat Commun, 7:13609-13609, 2016 Cited by PubMed: 28000660 DOI: 10.1038/ncomms13609 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.751 Å)

Structure validation