5IKW

Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor

Summary for 5IKW

• Entry DOI: 10.2210/pdb5ikw/pdb
• Descriptor: BMP-2-inducible protein kinase, N-(6-{3-[(cyclopropylsulfonyl)amino]phenyl}-1H-indazol-3-yl)cyclopropanecarboxamide (3 entities in total)
• Functional Keywords: transferase, protein kinase domain, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : Q9NSY1
• Total number of polymer chains: 1
• Total formula weight: 35187.50

Authors

Counago, R.M.,Sorrell, F.J.,Krojer, T.,Savitsky, P.,Elkins, J.M.,Axtman, A.,Drewry, D.,Wells, C.,Zhang, C.,Zuercher, W.,Willson, T.M.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Arruda, P.,Gileadi, O.,Structural Genomics Consortium (SGC) (deposition date: 2016-03-04, release date: 2016-06-29, Last modification date: 2024-01-10)

• Primary citation: Counago, R.M.,Sorrell, F.J.,Krojer, T.,Savitsky, P.,Elkins, J.M.,Axtman, A.,Drewry, D.,Wells, C.,Zhang, C.,Zuercher, W.,Willson, T.M.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Arruda, P.,Gileadi, O.,Structural Genomics Consortium (SGC); Crystal Structure of BMP-2-inducible kinase in complex with a 3-acylaminoindazole inhibitor GSK3236425A; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.41 Å)