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5IKW

Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue 6BU A 4000
ChainResidue
ALEU57
AARG134
AGLY136
AGLN137
AGLU184
AASN185
ALEU187
AALA58
ASER63
AVAL65
AALA77
AMET130
AGLU131
ATYR132
ACYS133

Functional Information from PROSITE/UniProt
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKveNILL
ChainResidueDetails
AILE176-LEU188

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP180

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU57
ALYS79

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PDB entries from 2024-07-10

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