5IKT

The Structure of Tolfenamic Acid Bound to Human Cyclooxygenase-2

5IKT の概要

• エントリーDOI: 10.2210/pdb5ikt/pdb
• 関連するPDBエントリー: 5IKQ 5IKR 5IKV
• 分子名称: Prostaglandin G/H synthase 2, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: cox tolfenamic, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 131426.15

構造登録者

Orlando, B.J.,Malkowski, M.G. (登録日: 2016-03-03, 公開日: 2016-05-25, 最終更新日: 2020-07-29)

• 主引用文献: Orlando, B.J.,Malkowski, M.G.; Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone.; J.Biol.Chem., 291:15069-15081, 2016; PubMed: 27226593; DOI: 10.1074/jbc.M116.725713

実験手法

X-RAY DIFFRACTION (2.451 Å)