5IJ7
Structure of Hs/AcPRC2 in complex with a pyridone inhibitor
Summary for 5IJ7
Entry DOI | 10.2210/pdb5ij7/pdb |
Related | 5IJ8 |
Descriptor | Enhancer of Zeste Homolog 2 (EZH2),Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ... (6 entities in total) |
Functional Keywords | lysine methyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Anolis carolinensis (Green anole) More |
Cellular location | Nucleus : Q15910 O75530 Q15022 |
Total number of polymer chains | 6 |
Total formula weight | 275962.15 |
Authors | Gajiwala, K.S.,Brooun, A.,Deng, Y.-L.,Liu, W. (deposition date: 2016-03-01, release date: 2016-05-04, Last modification date: 2024-03-06) |
Primary citation | Brooun, A.,Gajiwala, K.S.,Deng, Y.L.,Liu, W.,Bolanos, B.,Bingham, P.,He, Y.A.,Diehl, W.,Grable, N.,Kung, P.P.,Sutton, S.,Maegley, K.A.,Yu, X.,Stewart, A.E. Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance. Nat Commun, 7:11384-11384, 2016 Cited by PubMed: 27122193DOI: 10.1038/ncomms11384 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.62 Å) |
Structure validation
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