Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0042054 | molecular_function | histone methyltransferase activity |
| A | 0046976 | molecular_function | histone H3K27 methyltransferase activity |
| B | 0006338 | biological_process | chromatin remodeling |
| B | 0042054 | molecular_function | histone methyltransferase activity |
| B | 0046976 | molecular_function | histone H3K27 methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue 6BN A 9001 |
| Chain | Residue |
| A | ILE109 |
| A | ARG685 |
| A | PHE686 |
| A | ASN688 |
| A | HOH9101 |
| E | ARG222 |
| E | ASP223 |
| A | MET110 |
| A | TYR111 |
| A | GLY623 |
| A | TRP624 |
| A | VAL657 |
| A | TYR658 |
| A | TYR661 |
| A | PHE665 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 9002 |
| Chain | Residue |
| A | CYS530 |
| A | CYS543 |
| A | CYS549 |
| A | CYS553 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 9003 |
| Chain | Residue |
| A | CYS523 |
| A | CYS536 |
| A | CYS543 |
| A | CYS547 |
| A | ZN9004 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 9004 |
| Chain | Residue |
| A | CYS523 |
| A | HIS525 |
| A | CYS530 |
| A | CYS534 |
| A | ZN9003 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 9005 |
| Chain | Residue |
| A | CYS560 |
| A | CYS573 |
| A | CYS580 |
| A | CYS585 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 9006 |
| Chain | Residue |
| A | CYS566 |
| A | CYS580 |
| A | CYS588 |
| A | CYS601 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 9007 |
| Chain | Residue |
| A | CYS560 |
| A | CYS562 |
| A | CYS566 |
| A | CYS571 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 9008 |
| Chain | Residue |
| A | CYS286 |
| A | CYS289 |
| A | CYS294 |
| A | HIS297 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | binding site for residue 6BN B 9001 |
| Chain | Residue |
| B | ILE109 |
| B | MET110 |
| B | TYR111 |
| B | GLY623 |
| B | TRP624 |
| B | VAL657 |
| B | TYR658 |
| B | TYR661 |
| B | PHE665 |
| B | ARG685 |
| B | PHE686 |
| B | ASN688 |
| F | ARG222 |
| F | ASP223 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 9002 |
| Chain | Residue |
| B | CYS523 |
| B | HIS525 |
| B | CYS530 |
| B | CYS534 |
| B | ZN9003 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 9003 |
| Chain | Residue |
| B | CYS523 |
| B | CYS536 |
| B | CYS543 |
| B | CYS547 |
| B | ZN9002 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 9004 |
| Chain | Residue |
| B | CYS530 |
| B | CYS543 |
| B | CYS549 |
| B | CYS553 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 9005 |
| Chain | Residue |
| B | CYS560 |
| B | CYS562 |
| B | CYS566 |
| B | CYS571 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 9006 |
| Chain | Residue |
| B | CYS566 |
| B | CYS580 |
| B | CYS588 |
| B | CYS601 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 9007 |
| Chain | Residue |
| B | CYS560 |
| B | CYS573 |
| B | CYS580 |
| B | CYS585 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 9008 |
| Chain | Residue |
| B | CYS286 |
| B | CYS289 |
| B | CYS294 |
| B | HIS297 |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI |
| Chain | Residue | Details |
| E | LEU192-ILE206 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 230 |
| Details | Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 58 |
| Details | Region: {"description":"Interaction with EED","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKB/AKT1","evidences":[{"source":"PubMed","id":"16224021","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 86 |
| Details | Repeat: {"description":"WD 1"} |
| site_id | SWS_FT_FI9 |
| Number of Residues | 86 |
| Details | Repeat: {"description":"WD 2"} |
| site_id | SWS_FT_FI10 |
| Number of Residues | 80 |
| Details | Repeat: {"description":"WD 3"} |
| site_id | SWS_FT_FI11 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"WD 4"} |
| site_id | SWS_FT_FI12 |
| Number of Residues | 74 |
| Details | Repeat: {"description":"WD 5"} |
| site_id | SWS_FT_FI13 |
| Number of Residues | 308 |
| Details | Region: {"description":"Required for interaction with the matrix protein MA of HIV-1"} |
| site_id | SWS_FT_FI14 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"20974918","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI15 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"WD 6"} |
| site_id | SWS_FT_FI16 |
| Number of Residues | 152 |
| Details | Region: {"description":"VEFS-box"} |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"}]} |
