5IHA

MELK in complex with NVS-MELK8F

Summary for 5IHA

Entry DOI	10.2210/pdb5iha/pdb
Related	5HI9 5HIC 5IH8
Descriptor	Maternal embryonic leucine zipper kinase, 1-methyl-4-(4-{4-[3-(2-methylpropoxy)pyridin-4-yl]-1H-pyrazol-1-yl}phenyl)piperazine (3 entities in total)
Functional Keywords	kinase uba domain inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Peripheral membrane protein : Q14680
Total number of polymer chains	1
Total formula weight	39350.59
Authors	Sprague, E.R.,Brazell, T. (deposition date: 2016-02-29, release date: 2016-06-01, Last modification date: 2024-03-06)
Primary citation	Toure, B.B.,Giraldes, J.,Smith, T.,Sprague, E.R.,Wang, Y.,Mathieu, S.,Chen, Z.,Mishina, Y.,Feng, Y.,Yan-Neale, Y.,Shakya, S.,Chen, D.,Meyer, M.,Puleo, D.,Brazell, J.T.,Straub, C.,Sage, D.,Wright, K.,Yuan, Y.,Chen, X.,Duca, J.,Kim, S.,Tian, L.,Martin, E.,Hurov, K.,Shao, W. Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. J.Med.Chem., 59:4711-4723, 2016 Cited by PubMed: 27187609 DOI: 10.1021/acs.jmedchem.6b00052 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.96 Å)

Structure validation