5IGM

Crystal structure of the bromodomain of human BRD9 in complex with bromosporine (BSP)

Summary for 5IGM

Entry DOI	10.2210/pdb5igm/pdb
Descriptor	Bromodomain-containing protein 9, Bromosporine (3 entities in total)
Functional Keywords	chromatin remodeling, transcription, structural genomics, structural genomics consortium, sgc
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	29308.41
Authors	Tallant, C.,Filippakopoulos, P.,Picaud, S.,Nunez-Alonso, G.,von Delft, F.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2016-02-28, release date: 2016-10-19, Last modification date: 2024-01-10)
Primary citation	Picaud, S.,Leonards, K.,Lambert, J.P.,Dovey, O.,Wells, C.,Fedorov, O.,Monteiro, O.,Fujisawa, T.,Wang, C.Y.,Lingard, H.,Tallant, C.,Nikbin, N.,Guetzoyan, L.,Ingham, R.,Ley, S.V.,Brennan, P.,Muller, S.,Samsonova, A.,Gingras, A.C.,Schwaller, J.,Vassiliou, G.,Knapp, S.,Filippakopoulos, P. Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia. Sci Adv, 2:e1600760-e1600760, 2016 Cited by PubMed: 27757418 DOI: 10.1126/sciadv.1600760 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation