5IG6
Ultra-high resolution crystal structure of second bromodomain of BRD2 in complex with inhibitor 6B3
Summary for 5IG6
| Entry DOI | 10.2210/pdb5ig6/pdb |
| Related | 5IBN |
| Descriptor | Bromodomain-containing protein 2, CHLORIDE ION, GLYCEROL, ... (5 entities in total) |
| Functional Keywords | bet-family, inhibitor, transcription |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus : P25440 |
| Total number of polymer chains | 1 |
| Total formula weight | 14170.00 |
| Authors | Tripathi, S.K.,Padmanabhan, B. (deposition date: 2016-02-27, release date: 2016-06-22, Last modification date: 2023-11-08) |
| Primary citation | Tripathi, S.,Mathur, S.,Deshmukh, P.,Manjula, R.,Padmanabhan, B. A Novel Phenanthridionone Based Scaffold As a Potential Inhibitor of the BRD2 Bromodomain: Crystal Structure of the Complex Plos One, 11:e0156344-e0156344, 2016 Cited by PubMed: 27243809DOI: 10.1371/journal.pone.0156344 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (0.91 Å) |
Structure validation
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