5IFU
Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum in complex with Glyburide
Summary for 5IFU
Entry DOI | 10.2210/pdb5ifu/pdb |
Related | 4NCX 4Q15 4WI1 |
Descriptor | Proline--tRNA ligase, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | plasmodium falciparum, prolyl-trna synthetase, prors, proline--trna ligase, glyburide, structural genomics, structural genomics consortium, sgc, ligase |
Biological source | Plasmodium falciparum (isolate 3D7) |
Cellular location | Cytoplasm : Q8I5R7 |
Total number of polymer chains | 2 |
Total formula weight | 119764.94 |
Authors | Dranow, D.M.,Hewitt, S.N.,Abendroth, J.,Structural Genomics Consortium (SGC) (deposition date: 2016-02-26, release date: 2016-11-16, Last modification date: 2023-09-27) |
Primary citation | Hewitt, S.N.,Dranow, D.M.,Horst, B.G.,Abendroth, J.A.,Forte, B.,Hallyburton, I.,Jansen, C.,Baragana, B.,Choi, R.,Rivas, K.L.,Hulverson, M.A.,Dumais, M.,Edwards, T.E.,Lorimer, D.D.,Fairlamb, A.H.,Gray, D.W.,Read, K.D.,Lehane, A.M.,Kirk, K.,Myler, P.J.,Wernimont, A.,Walpole, C.,Stacy, R.,Barrett, L.K.,Gilbert, I.H.,Van Voorhis, W.C. Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase. ACS Infect Dis, 3:34-44, 2017 Cited by PubMed: 27798837DOI: 10.1021/acsinfecdis.6b00078 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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