5IFL

Crystal structure of B. pseudomallei FabI in complex with NAD and triclosan

Summary for 5IFL

Entry DOI	10.2210/pdb5ifl/pdb
Descriptor	Enoyl-[acyl-carrier-protein] reductase [NADH], TRICLOSAN, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (4 entities in total)
Functional Keywords	enoyl-acp reductase, burkholderia pseudomallei, diphenyl ethers, slow-binding inhibitors, oxidoreductase
Biological source	Burkholderia pseudomallei
Total number of polymer chains	16
Total formula weight	484453.73
Authors	Hirschbeck, M.W.,Eltschkner, S.,Tonge, P.J.,Kisker, C. (deposition date: 2016-02-26, release date: 2017-03-01, Last modification date: 2024-01-10)
Primary citation	Neckles, C.,Eltschkner, S.,Cummings, J.E.,Hirschbeck, M.,Daryaee, F.,Bommineni, G.R.,Zhang, Z.,Spagnuolo, L.,Yu, W.,Davoodi, S.,Slayden, R.A.,Kisker, C.,Tonge, P.J. Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase. Biochemistry, 56:1865-1878, 2017 Cited by PubMed: 28225601 DOI: 10.1021/acs.biochem.6b01048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation