5ICP
CDK8-CYCC IN COMPLEX WITH [(S)-2-(4-Chloro-phenyl)-pyrrolidin-1-yl]-(5-methyl-imidazo[5,1-b][1,3,4]thiadiazol-2-yl)-methanone
Summary for 5ICP
Entry DOI | 10.2210/pdb5icp/pdb |
Related | 5HBN |
Descriptor | Cyclin-dependent kinase 8, Cyclin-C, [(2S)-2-(4-chlorophenyl)pyrrolidin-1-yl](5-methylimidazo[5,1-b][1,3,4]thiadiazol-2-yl)methanone, ... (6 entities in total) |
Functional Keywords | cdk8 kinase / cyclin c, transferase |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : P49336 P24863 |
Total number of polymer chains | 2 |
Total formula weight | 75155.68 |
Authors | Musil, D.,Blagg, J.,Mallinger, A.,Czodrowski, P.,Schiemann, K. (deposition date: 2016-02-23, release date: 2016-12-21, Last modification date: 2024-01-10) |
Primary citation | Czodrowski, P.,Mallinger, A.,Wienke, D.,Esdar, C.,Poschke, O.,Busch, M.,Rohdich, F.,Eccles, S.A.,Ortiz-Ruiz, M.J.,Schneider, R.,Raynaud, F.I.,Clarke, P.A.,Musil, D.,Schwarz, D.,Dale, T.,Urbahns, K.,Blagg, J.,Schiemann, K. Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening. J. Med. Chem., 59:9337-9349, 2016 Cited by PubMed: 27490956DOI: 10.1021/acs.jmedchem.6b00597 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.18 Å) |
Structure validation
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