5ICN
HDAC1:MTA1 in complex with inositol-6-phosphate and a novel peptide inhibitor based on histone H4
Summary for 5ICN
Entry DOI | 10.2210/pdb5icn/pdb |
Descriptor | Metastasis-associated protein MTA1, Histone deacetylase 1, GLY-ALA-6A0-ARG-HIS, ... (6 entities in total) |
Functional Keywords | transcription repression inositol phosphate corepressor histone deacetylase hdac1 hdac3 histones, transcription, metastasis associated protein, ip6 |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 67157.56 |
Authors | Millard, C.J.,Robertson, N.S.,Watson, P.J.,Jameson, A.G.,Schwabe, J.W.R. (deposition date: 2016-02-23, release date: 2016-05-11, Last modification date: 2024-01-10) |
Primary citation | Watson, P.J.,Millard, C.J.,Riley, A.M.,Robertson, N.S.,Wright, L.C.,Godage, H.Y.,Cowley, S.M.,Jamieson, A.G.,Potter, B.V.,Schwabe, J.W. Insights into the activation mechanism of class I HDAC complexes by inositol phosphates. Nat Commun, 7:11262-11262, 2016 Cited by PubMed: 27109927DOI: 10.1038/ncomms11262 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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