5IAW

Novel natural FXR modulator with a unique binding mode

5IAW の概要

• エントリーDOI: 10.2210/pdb5iaw/pdb
• 分子名称: Bile acid receptor, Peptide from Nuclear receptor coactivator 2, (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 4-hydroxybenzoate, ... (4 entities in total)
• 機能のキーワード: nuclear protein receptor, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus . Isoform 1: Nucleus . Isoform 2: Nucleus . Isoform 3: Nucleus . Isoform 4: Nucleus : Q96RI1
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 56611.34

構造登録者

Lu, Y.,Li, Y. (登録日: 2016-02-22, 公開日: 2017-03-08, 最終更新日: 2024-03-20)

• 主引用文献: Zheng, W.,Lu, Y.,Lin, S.,Wang, R.,Qiu, L.,Zhu, Y.,Yao, B.,Guo, F.,Jin, S.,Jin, L.,Li, Y.; A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly; Chembiochem, 18:721-725, 2017; PubMed: 28186695; DOI: 10.1002/cbic.201700059

実験手法

X-RAY DIFFRACTION (2.58 Å)