5I9I
Crystal structure of LP_PLA2 in complex with Darapladib
Summary for 5I9I
Entry DOI | 10.2210/pdb5i9i/pdb |
Related | 5I8P |
Descriptor | Platelet-activating factor acetylhydrolase, N-[2-(diethylamino)ethyl]-2-{2-[(4-fluorobenzyl)sulfanyl]-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl}-N-{[ 4'-(trifluoromethyl)biphenyl-4-yl]methyl}acetamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | lp_pla2 inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted, extracellular space: Q13093 |
Total number of polymer chains | 2 |
Total formula weight | 89337.30 |
Authors | |
Primary citation | Liu, Q.F.,Chen, X.D.,Chen, W.Y.,Yuan, X.J.,Su, H.X.,Shen, J.H.,Xu, Y.C. Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors J.Med.Chem., 59:5115-5120, 2016 Cited by PubMed: 27078579DOI: 10.1021/acs.jmedchem.6b00282 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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