5I9I
Crystal structure of LP_PLA2 in complex with Darapladib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Platelet-activating factor acetylhydrolase | polymer | 388 | 43905.8 | 2 | UniProt (Q13093) Pfam (PF03403) | Homo sapiens (Human) | PAF acetylhydrolase,1-alkyl-2-acetylglycerophosphocholine esterase,2-acetyl-1-alkylglycerophosphocholine esterase,Group-VIIA phospholipase A2,gVIIA-PLA2,LDL-associated phospholipase A2,LDL-PLA(2),PAF 2-acylhydrolase |
| 2 | C, D (A, B) | N-[2-(diethylamino)ethyl]-2-{2-[(4-fluorobenzyl)sulfanyl]-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl}-N-{[ 4'-(trifluoromethyl)biphenyl-4-yl]methyl}acetamide | non-polymer | 666.8 | 2 | Chemie (5HV) | |||
| 3 | E, F (B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A, B: 47 - 429 (UniProt: Q13093)
| PDB | External Database | Details |
|---|---|---|
| Gly 42 | - | expression tag |
| Pro 43 | - | expression tag |
| Leu 44 | - | expression tag |
| Gly 45 | - | expression tag |
| Ser 46 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 87811.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1525.7 | |
| All* | Total formula weight | 89337.3 |
