5I8P
Crystal structure of LP_PLA2 in complex with novel inhibitor
Summary for 5I8P
Entry DOI | 10.2210/pdb5i8p/pdb |
Related | 5I9I |
Descriptor | Platelet-activating factor acetylhydrolase, 6-[1,1-bis(oxidanylidene)-1,4-thiazinan-4-yl]-4-[[4-[4-chloranyl-3-(trifluoromethyl)phenoxy]-3,5-bis(fluoranyl)phenyl]methoxy]-1-methyl-pyrimidin-2-one (3 entities in total) |
Functional Keywords | lp_pla2 inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted, extracellular space: Q13093 |
Total number of polymer chains | 2 |
Total formula weight | 88971.48 |
Authors | |
Primary citation | Liu, Q.F.,Chen, X.D.,Chen, W.Y.,Yuan, X.J.,Su, H.X.,Shen, J.H.,Xu, Y.C. Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors J.Med.Chem., 59:5115-5120, 2016 Cited by PubMed: 27078579DOI: 10.1021/acs.jmedchem.6b00282 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.37 Å) |
Structure validation
Download full validation report