5I95
Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase R140Q Mutant Homodimer bound to NADPH and alpha-Ketoglutaric acid
Summary for 5I95
Entry DOI | 10.2210/pdb5i95/pdb |
Related | 5I96 |
Descriptor | Isocitrate dehydrogenase [NADP], mitochondrial, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CALCIUM ION, ... (7 entities in total) |
Functional Keywords | idh, icd-m, idp nadp(+)-specific icdh oxalosuccinate decarboxylase, akg, alphakg, oxo-glutarate., oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Mitochondrion: P48735 |
Total number of polymer chains | 1 |
Total formula weight | 49489.87 |
Authors | Zhang, B.,Jin, L.,Wu, W.,Jiang, F.,DeLaBarre, B.,Travins, J.A.,Padyana, A.K. (deposition date: 2016-02-19, release date: 2017-03-01, Last modification date: 2023-09-27) |
Primary citation | Yen, K.,Travins, J.,Wang, F.,David, M.D.,Artin, E.,Straley, K.,Padyana, A.,Gross, S.,DeLaBarre, B.,Tobin, E.,Chen, Y.,Nagaraja, R.,Choe, S.,Jin, L.,Konteatis, Z.,Cianchetta, G.,Saunders, J.O.,Salituro, F.G.,Quivoron, C.,Opolon, P.,Bawa, O.,Saada, V.,Paci, A.,Broutin, S.,Bernard, O.A.,de Botton, S.,Marteyn, B.S.,Pilichowska, M.,Xu, Y.,Fang, C.,Jiang, F.,Wei, W.,Jin, S.,Silverman, L.,Liu, W.,Yang, H.,Dang, L.,Dorsch, M.,Penard-Lacronique, V.,Biller, S.A.,Su, S.M. AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations. Cancer Discov, 7:478-493, 2017 Cited by PubMed: 28193778DOI: 10.1158/2159-8290.CD-16-1034 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.54 Å) |
Structure validation
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