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5I94

Crystal structure of human glutaminase C in complex with the inhibitor UPGL-00019

Summary for 5I94
Entry DOI10.2210/pdb5i94/pdb
Related5FI2
DescriptorGlutaminase kidney isoform, mitochondrial, 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide (2 entities in total)
Functional Keywordsglutaminase c, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight238789.42
Authors
Huang, Q.,Cerione, R. (deposition date: 2016-02-19, release date: 2016-05-11, Last modification date: 2023-09-27)
Primary citationMcDermott, L.A.,Iyer, P.,Vernetti, L.,Rimer, S.,Sun, J.,Boby, M.,Yang, T.,Fioravanti, M.,O'Neill, J.,Wang, L.,Drakes, D.,Katt, W.,Huang, Q.,Cerione, R.
Design and evaluation of novel glutaminase inhibitors.
Bioorg.Med.Chem., 24:1819-1839, 2016
Cited by
PubMed: 26988803
DOI: 10.1016/j.bmc.2016.03.009
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.983 Å)
Structure validation

217705

건을2024-03-27부터공개중

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