5I8A

TrkA with (6~{R})-3-methylsulfanyl-6-phenyl-1-(1~{H}-pyrazol-3-yl)-6,7-dihydro-5~{H}-thieno[3,4-c]pyridin-4-one

Summary for 5I8A

Entry DOI	10.2210/pdb5i8a/pdb
Descriptor	High affinity nerve growth factor receptor, (6R)-3-(methylsulfanyl)-6-phenyl-1-(1H-pyrazol-3-yl)-6,7-dihydrothieno[3,4-c]pyridin-4(5H)-one, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	kinase, inhibitor, active site, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	34335.94
Authors	Su, H.P. (deposition date: 2016-02-18, release date: 2017-08-09, Last modification date: 2024-03-06)
Primary citation	Greshock, T.J.,Sanders, J.M.,Drolet, R.E.,Rajapakse, H.A.,Chang, R.K.,Kim, B.,Rada, V.L.,Tiscia, H.E.,Su, H.,Lai, M.T.,Sur, S.M.,Sanchez, R.I.,Bilodeau, M.T.,Renger, J.J.,Kern, J.T.,McCauley, J.A. Potent, selective and orally bioavailable leucine-rich repeat kinase 2 (LRRK2) inhibitors. Bioorg. Med. Chem. Lett., 26:2631-2635, 2016 Cited by PubMed: 27106707 DOI: 10.1016/j.bmcl.2016.04.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation