5I83
Crystal structure of the bromodomain of human CREBBP bound to the benzodiazepinone G02773986
Summary for 5I83
Entry DOI | 10.2210/pdb5i83/pdb |
Related | 5I86 5I89 |
Descriptor | CREB-binding protein, THIOCYANATE ION, (4R)-4-methyl-7-[(1R)-1-phenylethoxy]-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one, ... (4 entities in total) |
Functional Keywords | bromodomain inhibitor, protein binding-inhibitor complex, protein binding/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q92793 |
Total number of polymer chains | 1 |
Total formula weight | 14346.46 |
Authors | Jayaram, H.,Poy, F.,Setser, J.W.,Bellon, S.F. (deposition date: 2016-02-18, release date: 2016-04-20, Last modification date: 2023-09-27) |
Primary citation | Taylor, A.M.,Cote, A.,Hewitt, M.C.,Pastor, R.,Leblanc, Y.,Nasveschuk, C.G.,Romero, F.A.,Crawford, T.D.,Cantone, N.,Jayaram, H.,Setser, J.,Murray, J.,Beresini, M.H.,de Leon Boenig, G.,Chen, Z.,Conery, A.R.,Cummings, R.T.,Dakin, L.A.,Flynn, E.M.,Huang, O.W.,Kaufman, S.,Keller, P.J.,Kiefer, J.R.,Lai, T.,Li, Y.,Liao, J.,Liu, W.,Lu, H.,Pardo, E.,Tsui, V.,Wang, J.,Wang, Y.,Xu, Z.,Yan, F.,Yu, D.,Zawadzke, L.,Zhu, X.,Zhu, X.,Sims, R.J.,Cochran, A.G.,Bellon, S.,Audia, J.E.,Magnuson, S.,Albrecht, B.K. Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). Acs Med.Chem.Lett., 7:531-536, 2016 Cited by PubMed: 27190605DOI: 10.1021/acsmedchemlett.6b00075 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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