5I7U

Human DPP4 in complex with a novel tricyclic hetero-cycle inhibitor

Summary for 5I7U

• Entry DOI: 10.2210/pdb5i7u/pdb
• Descriptor: Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: structure-based drug design, diabetes, dpp4 inhibitors, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 174553.61

Authors

Scapin, G. (deposition date: 2016-02-18, release date: 2016-06-08, Last modification date: 2023-09-27)

• Primary citation: Wu, W.L.,Hao, J.,Domalski, M.,Burnett, D.A.,Pissarnitski, D.,Zhao, Z.,Stamford, A.,Scapin, G.,Gao, Y.D.,Soriano, A.,Kelly, T.M.,Yao, Z.,Powles, M.A.,Chen, S.,Mei, H.,Hwa, J.; Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes.; Acs Med.Chem.Lett., 7:498-501, 2016; PubMed: 27190600; DOI: 10.1021/acsmedchemlett.6b00027

Experimental method

X-RAY DIFFRACTION (1.95 Å)