5I6V
Structure of F285S, a Cancer-Associated Mutation of the Oncogenic Phosphatase SHP2
Summary for 5I6V
Entry DOI | 10.2210/pdb5i6v/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, GLYCEROL (3 entities in total) |
Functional Keywords | shp2, cancer-associated mutation, inhibitors, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q06124 |
Total number of polymer chains | 2 |
Total formula weight | 120559.91 |
Authors | Xu, X.,Blacklow, S.C. (deposition date: 2016-02-16, release date: 2016-04-13, Last modification date: 2023-09-27) |
Primary citation | LaRochelle, J.R.,Fodor, M.,Xu, X.,Durzynska, I.,Fan, L.,Stams, T.,Chan, H.M.,LaMarche, M.J.,Chopra, R.,Wang, P.,Fortin, P.D.,Acker, M.G.,Blacklow, S.C. Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2. Biochemistry, 55:2269-2277, 2016 Cited by PubMed: 27030275DOI: 10.1021/acs.biochem.5b01287 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.87 Å) |
Structure validation
Download full validation report