5I6C

The structure of the eukaryotic purine/H+ symporter, UapA, in complex with Xanthine

Summary for 5I6C

DescriptorUric acid-xanthine permease, XANTHINE, DODECYL-BETA-D-MALTOSIDE (3 entities in total)
Functional Keywordsmembrane protein eukaryotic uric acid/xanthine h+ symporter, transport protein
Biological sourceAspergillus nidulans FGSC A4
Cellular locationCell membrane ; Multi-pass membrane protein  Q07307
Total number of polymer chains2
Total molecular weight124755.71
Authors
Alguel, Y.,Amillis, S.,Leung, J.,Lambrinidis, G.,Capaldi, S.,Scull, N.J.,Craven, G.,Iwata, S.,Armstrong, A.,Mikros, E.,Diallinas, G.,Cameron, A.D.,Byrne, B. (deposition date: 2016-02-16, release date: 2016-04-27, Last modification date: 2017-08-30)
Primary citation
Alguel, Y.,Amillis, S.,Leung, J.,Lambrinidis, G.,Capaldi, S.,Scull, N.J.,Craven, G.,Iwata, S.,Armstrong, A.,Mikros, E.,Diallinas, G.,Cameron, A.D.,Byrne, B.
Structure of eukaryotic purine/H(+) symporter UapA suggests a role for homodimerization in transport activity.
Nat Commun, 7:11336-11336, 2016
PubMed: 27088252 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms11336
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.304121.7%0.5%9.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report