5I50

Structure of OmoMYC bound to double-stranded DNA

Summary for 5I50

• Entry DOI: 10.2210/pdb5i50/pdb
• Descriptor: Myc proto-oncogene protein, DNA (5'-D(P*CP*AP*CP*CP*CP*GP*GP*TP*CP*AP*CP*GP*TP*GP*GP*CP*CP*TP*AP*CP*AP*C)-3'), DNA (5'-D(P*GP*TP*GP*TP*AP*GP*GP*CP*CP*AP*CP*GP*TP*GP*AP*CP*CP*GP*GP*GP*TP*G)-3') (3 entities in total)
• Functional Keywords: leucine zipper, transcription factor, tumor suppressor, e-box, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 41579.79

Authors

Koelmel, W.,Jung, L.A.,Kuper, J.,Eilers, M.,Kisker, C. (deposition date: 2016-02-13, release date: 2016-10-26, Last modification date: 2024-01-10)

• Primary citation: Jung, L.A.,Gebhardt, A.,Koelmel, W.,Ade, C.P.,Walz, S.,Kuper, J.,von Eyss, B.,Letschert, S.,Redel, C.,d'Artista, L.,Biankin, A.,Zender, L.,Sauer, M.,Wolf, E.,Evan, G.,Kisker, C.,Eilers, M.; OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.; Oncogene, 36:1911-1924, 2017; PubMed: 27748763; DOI: 10.1038/onc.2016.354

Experimental method

X-RAY DIFFRACTION (2.701 Å)