5I50
Structure of OmoMYC bound to double-stranded DNA
Summary for 5I50
Entry DOI | 10.2210/pdb5i50/pdb |
Descriptor | Myc proto-oncogene protein, DNA (5'-D(P*CP*AP*CP*CP*CP*GP*GP*TP*CP*AP*CP*GP*TP*GP*GP*CP*CP*TP*AP*CP*AP*C)-3'), DNA (5'-D(P*GP*TP*GP*TP*AP*GP*GP*CP*CP*AP*CP*GP*TP*GP*AP*CP*CP*GP*GP*GP*TP*G)-3') (3 entities in total) |
Functional Keywords | leucine zipper, transcription factor, tumor suppressor, e-box, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 41579.79 |
Authors | Koelmel, W.,Jung, L.A.,Kuper, J.,Eilers, M.,Kisker, C. (deposition date: 2016-02-13, release date: 2016-10-26, Last modification date: 2024-01-10) |
Primary citation | Jung, L.A.,Gebhardt, A.,Koelmel, W.,Ade, C.P.,Walz, S.,Kuper, J.,von Eyss, B.,Letschert, S.,Redel, C.,d'Artista, L.,Biankin, A.,Zender, L.,Sauer, M.,Wolf, E.,Evan, G.,Kisker, C.,Eilers, M. OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors. Oncogene, 36:1911-1924, 2017 Cited by PubMed: 27748763DOI: 10.1038/onc.2016.354 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.701 Å) |
Structure validation
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