5I50

Structure of OmoMYC bound to double-stranded DNA

5I50 の概要

• エントリーDOI: 10.2210/pdb5i50/pdb
• 分子名称: Myc proto-oncogene protein, DNA (5'-D(P*CP*AP*CP*CP*CP*GP*GP*TP*CP*AP*CP*GP*TP*GP*GP*CP*CP*TP*AP*CP*AP*C)-3'), DNA (5'-D(P*GP*TP*GP*TP*AP*GP*GP*CP*CP*AP*CP*GP*TP*GP*AP*CP*CP*GP*GP*GP*TP*G)-3') (3 entities in total)
• 機能のキーワード: leucine zipper, transcription factor, tumor suppressor, e-box, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 41579.79

構造登録者

Koelmel, W.,Jung, L.A.,Kuper, J.,Eilers, M.,Kisker, C. (登録日: 2016-02-13, 公開日: 2016-10-26, 最終更新日: 2024-01-10)

• 主引用文献: Jung, L.A.,Gebhardt, A.,Koelmel, W.,Ade, C.P.,Walz, S.,Kuper, J.,von Eyss, B.,Letschert, S.,Redel, C.,d'Artista, L.,Biankin, A.,Zender, L.,Sauer, M.,Wolf, E.,Evan, G.,Kisker, C.,Eilers, M.; OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.; Oncogene, 36:1911-1924, 2017; PubMed: 27748763; DOI: 10.1038/onc.2016.354

実験手法

X-RAY DIFFRACTION (2.701 Å)