5I4U

The crystal structure of PI3Kdelta with compound 34

Summary for 5I4U

• Entry DOI: 10.2210/pdb5i4u/pdb
• Related: 5I6U
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 2,4-diamino-6-{[(1S)-1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl]amino}pyrimidine-5-carbonitrile (3 entities in total)
• Functional Keywords: kinase, p110, kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mus musculus (Mouse)
• Cellular location: Cytoplasm : O35904
• Total number of polymer chains: 1
• Total formula weight: 108199.47

Authors

Somoza, J.R.,Villasenor, A.G. (deposition date: 2016-02-12, release date: 2017-02-22, Last modification date: 2023-09-27)

• Primary citation: Somoza, J.R.,Villasenor, G.A.; The Design and Synthesis of Potent, Selective and Metabolically Stable PI3K[delta] Inhibitors; To be published,

Experimental method

X-RAY DIFFRACTION (2.372 Å)