5I4U
The crystal structure of PI3Kdelta with compound 34
Summary for 5I4U
Entry DOI | 10.2210/pdb5i4u/pdb |
Related | 5I6U |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 2,4-diamino-6-{[(1S)-1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl]amino}pyrimidine-5-carbonitrile (3 entities in total) |
Functional Keywords | kinase, p110, kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mus musculus (Mouse) |
Cellular location | Cytoplasm : O35904 |
Total number of polymer chains | 1 |
Total formula weight | 108199.47 |
Authors | Somoza, J.R.,Villasenor, A.G. (deposition date: 2016-02-12, release date: 2017-02-22, Last modification date: 2023-09-27) |
Primary citation | Somoza, J.R.,Villasenor, G.A. The Design and Synthesis of Potent, Selective and Metabolically Stable PI3K[delta] Inhibitors To be published, |
Experimental method | X-RAY DIFFRACTION (2.372 Å) |
Structure validation
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