5I46

Factor VIIA in complex with the inhibitor (2R,15R)-2-[(1-aminoisoquinolin-6-yl)amino]-8-fluoro-7-hydroxy-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaene-3,12-dione

Summary for 5I46

• Entry DOI: 10.2210/pdb5i46/pdb
• Descriptor: Coagulation factor VII (Heavy Chain), Coagulation factor VII (Light Chain), (2R,15R)-2-[(1-aminoisoquinolin-6-yl)amino]-8-fluoro-7-hydroxy-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaene-3,12-dione, ... (7 entities in total)
• Functional Keywords: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: P08709 P08709
• Total number of polymer chains: 2
• Total formula weight: 35201.18

Authors

Wei, A. (deposition date: 2016-02-11, release date: 2016-06-22, Last modification date: 2023-09-27)

• Primary citation: Glunz, P.W.,Mueller, L.,Cheney, D.L.,Ladziata, V.,Zou, Y.,Wurtz, N.R.,Wei, A.,Wong, P.C.,Wexler, R.R.,Priestley, E.S.; Atropisomer Control in Macrocyclic Factor VIIa Inhibitors.; J.Med.Chem., 59:4007-4018, 2016; PubMed: 27015008; DOI: 10.1021/acs.jmedchem.6b00244

Experimental method

X-RAY DIFFRACTION (2.06 Å)