5I2E

Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound Sulfamate Inhibitor 3a:3-(5-O-{[3-(1H-indol-3-yl)propanoyl]sulfamoyl}-beta-D-ribofuranosyl)-3H-imidazo[2,1-i]purine

5I2E の概要

• エントリーDOI: 10.2210/pdb5i2e/pdb
• 関連するPDBエントリー: 3TW2 4EQE 4EQG 4EQH 5I2F
• 分子名称: Histidine triad nucleotide-binding protein 1, 3-(5-O-{[3-(1H-indol-3-yl)propanoyl]sulfamoyl}-beta-D-ribofuranosyl)-3H-imidazo[2,1-i]purine, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: hint, histidine triad, hit, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P49773
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28826.01

構造登録者

Strom, A.M.,Finzel, B.C.,Wagner, C.R. (登録日: 2016-02-08, 公開日: 2016-06-22, 最終更新日: 2023-09-27)

• 主引用文献: Shah, R.,Strom, A.,Zhou, A.,Maize, K.M.,Finzel, B.C.,Wagner, C.R.; Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1.; Acs Med.Chem.Lett., 7:780-784, 2016; PubMed: 27563403; DOI: 10.1021/acsmedchemlett.6b00169

実験手法

X-RAY DIFFRACTION (1.6 Å)