5I0B

Structure of PAK4

Summary for 5I0B

• Entry DOI: 10.2210/pdb5i0b/pdb
• Descriptor: Serine/threonine-protein kinase PAK 4, 6-bromo-2-[1-methyl-3-(propan-2-yl)-1H-pyrazol-4-yl]-1H-imidazo[4,5-b]pyridine (2 entities in total)
• Functional Keywords: kinase, transferase-transferase inihibitor complex, transferase/transferase inihibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : O96013
• Total number of polymer chains: 1
• Total formula weight: 33745.03

Authors

Park, S.Y. (deposition date: 2016-02-03, release date: 2016-12-14, Last modification date: 2023-11-08)

• Primary citation: Park, J.K.,Kim, S.,Han, Y.J.,Kim, S.H.,Kang, N.S.,Lee, H.,Park, S.Y.; The discovery and the structural basis of an imidazo[4,5-b]pyridine-based p21-activated kinase 4 inhibitor; Bioorg. Med. Chem. Lett., 26:2580-2583, 2016; PubMed: 27117431; DOI: 10.1016/j.bmcl.2016.04.037

Experimental method

X-RAY DIFFRACTION (3.09 Å)