5HY9

Glycosylated, disulfide-linked Knob-into-Hole Fc fragment

5HY9 の概要

• エントリーDOI: 10.2210/pdb5hy9/pdb
• 分子名称: Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: bispecific antibody fc engineering knob-into-hole, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Secreted : P01857 P01857
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53806.41

構造登録者

Kuglstatter, A.,Stihle, M.,Benz, J. (登録日: 2016-02-01, 公開日: 2017-02-01, 最終更新日: 2024-01-10)

• 主引用文献: Kuglstatter, A.,Stihle, M.,Neumann, C.,Muller, C.,Schaefer, W.,Klein, C.,Benz, J.; Structural differences between glycosylated, disulfide-linked heterodimeric Knob-into-Hole Fc fragment and its homodimeric Knob-Knob and Hole-Hole side products.; Protein Eng. Des. Sel., 30:649-656, 2017; PubMed: 28985438; DOI: 10.1093/protein/gzx041

実験手法

X-RAY DIFFRACTION (2.7 Å)