5HVW
Monomeric IgG4 Fc
Summary for 5HVW
Entry DOI | 10.2210/pdb5hvw/pdb |
Descriptor | Ig gamma-4 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (5 entities in total) |
Functional Keywords | biotechnology, antibody engineering, monomeric fc, monovalent targeting, fusion protein, immune system |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted: P01861 |
Total number of polymer chains | 1 |
Total formula weight | 25748.28 |
Authors | Oganesyan, V.Y.,Shan, L.,Dall'Acqua, W.F. (deposition date: 2016-01-28, release date: 2016-08-17, Last modification date: 2020-07-29) |
Primary citation | Shan, L.,Colazet, M.,Rosenthal, K.L.,Yu, X.Q.,Bee, J.S.,Ferguson, A.,Damschroder, M.M.,Wu, H.,Dall'Acqua, W.F.,Tsui, P.,Oganesyan, V. Generation and Characterization of an IgG4 Monomeric Fc Platform. Plos One, 11:e0160345-e0160345, 2016 Cited by PubMed: 27479095DOI: 10.1371/journal.pone.0160345 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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