5HVW

Monomeric IgG4 Fc

Summary for 5HVW

• Entry DOI: 10.2210/pdb5hvw/pdb
• Descriptor: Ig gamma-4 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (5 entities in total)
• Functional Keywords: biotechnology, antibody engineering, monomeric fc, monovalent targeting, fusion protein, immune system
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted: P01861
• Total number of polymer chains: 1
• Total formula weight: 25748.28

Authors

Oganesyan, V.Y.,Shan, L.,Dall'Acqua, W.F. (deposition date: 2016-01-28, release date: 2016-08-17, Last modification date: 2020-07-29)

• Primary citation: Shan, L.,Colazet, M.,Rosenthal, K.L.,Yu, X.Q.,Bee, J.S.,Ferguson, A.,Damschroder, M.M.,Wu, H.,Dall'Acqua, W.F.,Tsui, P.,Oganesyan, V.; Generation and Characterization of an IgG4 Monomeric Fc Platform.; Plos One, 11:e0160345-e0160345, 2016; PubMed: 27479095; DOI: 10.1371/journal.pone.0160345

Experimental method

X-RAY DIFFRACTION (1.95 Å)