5HVW

Monomeric IgG4 Fc

5HVW の概要

• エントリーDOI: 10.2210/pdb5hvw/pdb
• 分子名称: Ig gamma-4 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (5 entities in total)
• 機能のキーワード: biotechnology, antibody engineering, monomeric fc, monovalent targeting, fusion protein, immune system
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted: P01861
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25748.28

構造登録者

Oganesyan, V.Y.,Shan, L.,Dall'Acqua, W.F. (登録日: 2016-01-28, 公開日: 2016-08-17, 最終更新日: 2020-07-29)

• 主引用文献: Shan, L.,Colazet, M.,Rosenthal, K.L.,Yu, X.Q.,Bee, J.S.,Ferguson, A.,Damschroder, M.M.,Wu, H.,Dall'Acqua, W.F.,Tsui, P.,Oganesyan, V.; Generation and Characterization of an IgG4 Monomeric Fc Platform.; Plos One, 11:e0160345-e0160345, 2016; PubMed: 27479095; DOI: 10.1371/journal.pone.0160345

実験手法

X-RAY DIFFRACTION (1.95 Å)