5HVT
Crystal Structure of Macrophage Migration Inhibitory Factor (MIF) with a Potent Inhibitor (NVS-2)
Summary for 5HVT
Entry DOI | 10.2210/pdb5hvt/pdb |
Related | 5HVS |
Descriptor | Macrophage migration inhibitory factor, SULFATE ION, 7-hydroxy-3-(4-methoxyphenyl)-3,4-dihydro-2H-1,3-benzoxazin-2-one, ... (6 entities in total) |
Functional Keywords | cytokine, inhibitor, complex, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted : P14174 |
Total number of polymer chains | 3 |
Total formula weight | 38911.92 |
Authors | Robertson, M.J.,Jorgensen, W.L. (deposition date: 2016-01-28, release date: 2016-06-29, Last modification date: 2023-09-27) |
Primary citation | Cisneros, J.A.,Robertson, M.J.,Valhondo, M.,Jorgensen, W.L. A Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors. J.Am.Chem.Soc., 138:8630-8638, 2016 Cited by PubMed: 27299179DOI: 10.1021/jacs.6b04910 PDB entries with the same primary citation |
Experimental method |
Structure validation
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