5HVM
Structure of Aspergillus fumigatus trehalose-6-phosphate synthase A in complex with UDP and validoxylamine A
Summary for 5HVM
Entry DOI | 10.2210/pdb5hvm/pdb |
Related | 5HUO 5HUS 5HUT 5HUU 5HUV 5HVL |
Descriptor | Alpha,alpha-trehalose-phosphate synthase (UDP-forming), URIDINE-5'-DIPHOSPHATE, (1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL, ... (4 entities in total) |
Functional Keywords | trehalose-6-phosphate synthase, transferase |
Biological source | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) |
Total number of polymer chains | 2 |
Total formula weight | 117450.16 |
Authors | Miao, Y.,Brennan, R.G. (deposition date: 2016-01-28, release date: 2017-05-03, Last modification date: 2024-04-03) |
Primary citation | Miao, Y.,Tenor, J.L.,Toffaletti, D.L.,Maskarinec, S.A.,Liu, J.,Lee, R.E.,Perfect, J.R.,Brennan, R.G. Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design. MBio, 8:-, 2017 Cited by PubMed: 28743811DOI: 10.1128/mBio.00643-17 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.815 Å) |
Structure validation
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