5HVG

Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory Nanobody (VHH-a204)

5HVG の概要

• エントリーDOI: 10.2210/pdb5hvg/pdb
• 関連するPDBエントリー: 5HVF 5HVH
• 分子名称: Carboxypeptidase B2, VHH-a204, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: procarboxypeptidase u, thrombin-activatable fibrinolysis inhibitor, tafi, procarboxypeptidase r, plasma procarboxypeptidase b, nanobody, antibody fragment, protein complex, hydrolase/hydrolase inhibitor, hydrolase-hydrolase inhibitor complex
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 122698.04

構造登録者

Zhou, X.,Weeks, S.D.,Strelkov, S.V.,Declerck, P.J. (登録日: 2016-01-28, 公開日: 2016-06-22, 最終更新日: 2024-01-10)

• 主引用文献: Zhou, X.,Weeks, S.D.,Ameloot, P.,Callewaert, N.,Strelkov, S.V.,Declerck, P.J.; Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.; J.Thromb.Haemost., 14:1629-1638, 2016; PubMed: 27279497; DOI: 10.1111/jth.13381

実験手法

X-RAY DIFFRACTION (3.05 Å)