5HVG
Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory Nanobody (VHH-a204)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Carboxypeptidase B2 | polymer | 401 | 46080.2 | 2 | UniProt (Q96IY4) Pfam (PF02244) Pfam (PF00246) | Homo sapiens (Human) | Carboxypeptidase U,CPU,Plasma carboxypeptidase B,pCPB,Thrombin-activable fibrinolysis inhibitor,TAFI |
| 2 | B, D (B, D) | VHH-a204 | polymer | 128 | 14034.4 | 2 | Vicugna pacos (alpaca) | ||
| 3 | E (E) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 4 | F (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | G, H, I, L (A, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 6 | J, M (A, C) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 7 | K, N (A, C) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) |
Sequence modifications
A, C: 1 - 401 (UniProt: Q96IY4)
| PDB | External Database | Details |
|---|---|---|
| Cys 305 | Ser 327 | engineered mutation |
| Ile 329 | Thr 351 | engineered mutation |
| Tyr 333 | His 355 | engineered mutation |
| Gln 335 | His 357 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 120229.1 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1335.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1133.7 | |
| All* | Total formula weight | 122698.0 |
