5HVE
5-methyl-6-(3'-trifluromethoxyphenylthio)[2,3-d]pyrimidine 2,4-diamine
Summary for 5HVE
Entry DOI | 10.2210/pdb5hve/pdb |
Descriptor | Dihydrofolate reductase, 5-methyl-6-{[3-(trifluoromethoxy)phenyl]sulfanyl}thieno[2,3-d]pyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | dihydrofolate reductase inhibitor complex with nadph, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Mitochondrion : P00374 |
Total number of polymer chains | 1 |
Total formula weight | 22467.33 |
Authors | Cody, V. (deposition date: 2016-01-28, release date: 2017-02-01, Last modification date: 2023-09-27) |
Primary citation | Cody, V.,Gangjee, A. Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-(4'-methoxyphenythio)[2,3-d]pyrrolo-7-ethyl-2,4-diamines To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.46 Å) |
Structure validation
Download full validation report