5HVE
5-methyl-6-(3'-trifluromethoxyphenylthio)[2,3-d]pyrimidine 2,4-diamine
5HVE の概要
エントリーDOI | 10.2210/pdb5hve/pdb |
分子名称 | Dihydrofolate reductase, 5-methyl-6-{[3-(trifluoromethoxy)phenyl]sulfanyl}thieno[2,3-d]pyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
機能のキーワード | dihydrofolate reductase inhibitor complex with nadph, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Mitochondrion : P00374 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 22467.33 |
構造登録者 | |
主引用文献 | Cody, V.,Gangjee, A. Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-(4'-methoxyphenythio)[2,3-d]pyrrolo-7-ethyl-2,4-diamines To Be Published, |
実験手法 | X-RAY DIFFRACTION (1.46 Å) |
構造検証レポート
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