5HUI

6-substituted pyrido[3,2-d]pyrimidine--6-4'-trifluoromethoxyphenyl)

5HUI の概要

• エントリーDOI: 10.2210/pdb5hui/pdb
• 関連するPDBエントリー: 5HVB
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N~6~-methyl-N~6~-[4-(trifluoromethoxy)phenyl]pyrido[3,2-d]pyrimidine-2,4,6-triamine, ... (5 entities in total)
• 機能のキーワード: dihydrofolate reductase inhibitor complex with nadph, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Mitochondrion : P00374
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22541.31

構造登録者

Cody, V. (登録日: 2016-01-27, 公開日: 2017-02-01, 最終更新日: 2023-09-27)

• 主引用文献: Cody, V.,Gangjee, A.; Human dihydrofolate reductase ternary complex with a series of 6-substituted pyrido[3,2]pyrimidine-6-(4'-trifluoromethoxypheny)-2,4-diamines; To Be Published,

実験手法

X-RAY DIFFRACTION (1.46 Å)