5HTB
Crystal structure of haspin (GSG2) in complex with bisubstrate inhibitor ARC-3353
Summary for 5HTB
Entry DOI | 10.2210/pdb5htb/pdb |
Descriptor | Serine/threonine-protein kinase haspin, ARC-3353 inhibitor, (4R)-2-METHYLPENTANE-2,4-DIOL, ... (8 entities in total) |
Functional Keywords | transferase, kinase, inhibitor, allosteric, structural genomics consortium (sgc), transferase-transferase inhibitor complex, bisubstrate inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q8TF76 |
Total number of polymer chains | 2 |
Total formula weight | 42360.40 |
Authors | Chaikuad, A.,Heroven, C.,Lavogina, D.,Kestav, K.,Uri, A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2016-01-26, release date: 2016-05-11, Last modification date: 2023-04-26) |
Primary citation | Lavogina, D.,Kestav, K.,Chaikuad, A.,Heroven, C.,Knapp, S.,Uri, A. Co-crystal structures of the protein kinase haspin with bisubstrate inhibitors. Acta Crystallogr.,Sect.F, 72:339-345, 2016 Cited by PubMed: 27139824DOI: 10.1107/S2053230X16004611 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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