5HSR

Fluorine substituted 5-methyl-6-(3',4'-difluoromethoxyphenythio)thieno[2,3-d]pyrimidine-2,4-diamine

5HSR の概要

• エントリーDOI: 10.2210/pdb5hsr/pdb
• 関連するPDBエントリー: 5HSU
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-methyl-6-[(2,3,4-trifluorophenyl)sulfanyl]thieno[2,3-d]pyrimidine-2,4-diamine, ... (4 entities in total)
• 機能のキーワード: dihydrofolate reductase inhibitor complex with nadph, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Mitochondrion : P00374
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22779.67

構造登録者

Cody, V. (登録日: 2016-01-26, 公開日: 2017-02-01, 最終更新日: 2023-09-27)

• 主引用文献: Cody, V.,Gangjee, A.; Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-phenythio)thieno[2,3-d]pyrimidine-2,4-diamines; To Be Published,

実験手法

X-RAY DIFFRACTION (1.21 Å)