5HS6
Human 17beta-hydroxysteroid dehydrogenase type 14 in complex with Estrone
Summary for 5HS6
Entry DOI | 10.2210/pdb5hs6/pdb |
Related | 5EN4 |
Descriptor | 17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one, ... (5 entities in total) |
Functional Keywords | 17bhsd14, estrone complex, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q9BPX1 |
Total number of polymer chains | 1 |
Total formula weight | 29639.52 |
Authors | Bertoletti, N.,Marchais-Oberwinkler, S.,Heine, A.,Klebe, G. (deposition date: 2016-01-25, release date: 2016-07-13, Last modification date: 2024-01-10) |
Primary citation | Bertoletti, N.,Braun, F.,Lepage, M.,Moller, G.,Adamski, J.,Heine, A.,Klebe, G.,Marchais-Oberwinkler, S. New Insights into Human 17 beta-Hydroxysteroid Dehydrogenase Type 14: First Crystal Structures in Complex with a Steroidal Ligand and with a Potent Nonsteroidal Inhibitor. J.Med.Chem., 59:6961-6967, 2016 Cited by PubMed: 27362750DOI: 10.1021/acs.jmedchem.6b00293 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
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